The ADVOS method is essentially based on the principle of albumin dialysis. In contrast to conventional single-pass albumin dialysis, however, ADVOS allows for a significantly higher dialysate flow, lower albumin consumption and significantly higher detoxification performance.

Albumin is a protein in the human body that is used to transport water-insoluble substances such as fatty acids, bilirubin, trace elements, certain vitamins, hormones, metals and drugs. All these substances become transportable by binding to albumin. In contrast to normal kidney dialysis, in which only water-soluble toxins are eliminated, the ADVOS process additionally removes protein-bound hepatotoxins and nephrotoxins as well as CO2.


After the patients are connected to the multi-organ support device ADVOS multi by a conventional port or Shaldon catheter, the blood contaminated with toxins is passed through the ADVOS dialyzers and purified by means of albumin-enriched dialysate.

The dialysate binds both water-soluble and protein-bound toxins and is subsequently purified of toxins in the unique ADVOS circuit by chemical-physical processes and the resulting filtrates are disposed.

The ADVOS circuit itself consists of two partial circuits:

After filtration of the toxins, both loops are merged, hydrochloric acid and sodium hydroxide are neutralized to saline and water (HCl + NaOH = H2O + NaCl) and the purified, unsaturated albumin dialysate can be cycled through the dialyzer again in order to remove further toxins. Since the albumin is permanently purified and recycled, only a small amount of albumin is needed for efficient toxin removal.